Comparative analysis of human and bovine protein kinases reveals unique relationship and functional diversity
Genet. mol. biol
; 34(4): 587-591, 2011. graf, tab
Artigo
em Inglês
| LILACS
| ID: lil-605926
Biblioteca responsável:
BR1.1
ABSTRACT
Reversible protein phosphorylation by protein kinases and phosphatases is a common event in various cellular processes. The eukaryotic protein kinase superfamily, which is one of the largest superfamilies of eukaryotic proteins, plays several roles in cell signaling and diseases. We identified 482 eukaryotic protein kinases and 39 atypical protein kinases in the bovine genome, by searching publicly accessible genetic-sequence databases. Bovines have 512 putative protein kinases, each orthologous to a human kinase. Whereas orthologous kinase pairs are, on an average, 90.6 percent identical, orthologous kinase catalytic domain pairs are, on an average, 95.9 percent identical at the amino acid level. This bioinformatic study of bovine protein kinases provides a suitable framework for further characterization of their functional and structural properties.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Proteínas Quinases
/
Bovinos
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Genet. mol. biol
Assunto da revista:
Genética
Ano de publicação:
2011
Tipo de documento:
Artigo
País de afiliação:
Bangladesh
Instituição/País de afiliação:
Bagura Road/BD