Reactivity of macro-and microvessels of doca-salt hypertensive rats: role of the endothelial cell
Braz. j. med. biol. res
; 21(4): 845-9, 1988. ilus
Artigo
em Inglês
| LILACS
| ID: lil-60806
Biblioteca responsável:
BR26.1
ABSTRACT
The responses to noradrenaline (NA) and acetylcholine (ACh) of aortae and microvessels were cocmpared in control and DOCA-salt hypertensive rats. Macro - and microvessels from hypertensive rats showed an increased response to NA and a decreased response to ACh (an endothelium-dependent vasodilator). Unlike ACh, sodium nitroprusside (an endothelium-independent agent), was equally effective in evoking a vasodilator response from aortae and microvessels of hypertensive rats. These data suggest that the impaired response to ACh and the increased response to NA in DOCA-salt hypertension may result from an alteration of endothelial cell function
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Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Aorta
/
Endotélio Vascular
/
Acetilcolina
/
Norepinefrina
/
Desoxicorticosterona
/
Hipertensão
/
Artérias Mesentéricas
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1988
Tipo de documento:
Artigo
/
Congresso e conferência
/
Documento de projeto