Trypanosoma cruzi trypomastigotes induce cytoskeleton modifications during HeLa cell invasion
Mem. Inst. Oswaldo Cruz
; 106(8): 1014-1016, Dec. 2011. ilus
Artigo
em Inglês
| LILACS
| ID: lil-610979
Biblioteca responsável:
BR1.1
ABSTRACT
It has been recently shown that Trypanosoma cruzi trypomastigotes subvert a constitutive membrane repair mechanism to invade HeLa cells. Using a membrane extraction protocol and high-resolution microscopy, the HeLa cytoskeleton and T. cruzi parasites were imaged during the invasion process after 15 min and 45 min. Parasites were initially found under cells and were later observed in the cytoplasm. At later stages, parasite-driven protrusions with parallel filaments were observed, with trypomastigotes at their tips. We conclude that T. cruzi trypomastigotes induce deformations of the cortical actin cytoskeleton shortly after invasion, leading to the formation of pseudopod-like structures.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
Doenças Negligenciadas
Problema de saúde:
Doença de Chagas
/
Doenças Negligenciadas
Base de dados:
LILACS
Assunto principal:
Trypanosoma cruzi
/
Citoesqueleto
/
Membrana Celular
Limite:
Humanos
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2011
Tipo de documento:
Artigo
País de afiliação:
Brasil
/
Estados Unidos
Instituição/País de afiliação:
Universidade Federal de São Paulo/BR
/
University of Maryland/US