Cell-matrix interactions in Schistosomal portal fibrosis: a dynamic event
Mem. Inst. Oswaldo Cruz
; 82(supl.4): 55-65, 1987. ilus, tab
Article
em En
| LILACS
| ID: lil-623665
Biblioteca responsável:
BR1.1
ABSTRACT
In recent years, one of the most significant progress in the understanding of liver diseases was the demonstration that liver fibrosis is a dynamic process resulting from a balance between synthesis and degradation of several matrix components, collagen in particular. Thus, fibrosis has been found to be a very early event during liver diseases, be it of toxic, viral or parasitic origin, and to be spontaneously reversible, either partially or totally. In liver fibrosis cell matrix interactions are dependent on the existence of the many factors (sometimes acting in combination) which produce the same events at the cellular and molecular levels. These events are (i) the recruitment of fiber-producing cells, (ii) their proliferation, (iii) the secretion of matrix constituents of the extracellular matrix, and (iv) the remodeling and degradation of the newly formed matrix. All these events represent, at least in principle, a target for a therapeutic intervention aimed at influencing the experimentally induced hepatic fibrosis. In this context, hepatosplenic schistosomiasis is of particular interest, being an immune cell-mediated granulomatous disease and a model of liver fibrosis allowing extensive studies in human and animals as well as providing original in vitro models.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Schistosoma
/
Esquistossomose
/
Vasculite
/
Fatores Biológicos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Ano de publicação:
1987
Tipo de documento:
Article
/
Congress and conference
País de afiliação:
França
País de publicação:
Brasil