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Seroprevalence of Leptospira in Rattus Norvegicus in Grenada, West Indies
Keenan, J; Sharma, R; Dicker, R; Rayner, J; Stone, D.
Afiliação
  • Keenan, J; St George's University. School of Medicine. Department of Public Health and Preventive Medicine. Grenada. GD
  • Sharma, R; St George's University. School of Medicine. Department of Public Health and Preventive Medicine. Grenada. GD
  • Dicker, R; St George's University. School of Medicine. Department of Public Health and Preventive Medicine. Grenada. GD
  • Rayner, J; St George's University. School of Medicine. Department of Public Health and Preventive Medicine. Grenada. GD
  • Stone, D; St George's University. School of Medicine. Department of Public Health and Preventive Medicine. Grenada. GD
West Indian med. j ; 58(2): 114-117, Mar. 2009. graf, tab
Article em En | LILACS | ID: lil-672453
Biblioteca responsável: BR1.1
ABSTRACT
OBJETIVE To determine the seroprevalence of Leptospira and the serovars responsible for Leptospira exposure in rats in Grenada in order to assess rats as a reservoir host for human infection. DESIGN AND

METHODS:

Rattus norvegicus rodents were collected representing each of the six parishes on the island of Grenada. Serum from 237 rats was tested by the microscopic agglutination test (MAT) and an Immunoglobulin G (IgG) Enzyme-Linked Immunosorbent Assay (ELISA). Seroprevalence rates among parishes were compared using a chi-squared test of homogeneity.

RESULTS:

Of the 237 serum samples tested, 64 were positive by either MAT or ELISA for an overall seroprevalence of 27%. The ELISA identified 24.5 % (57/233) of the rats positive at a titer of > 1160. The MAT identified 7.1% (13/183) of the rats positive at a titer of > 1100. Six of the 13 MAT positive samples had antibodies to multiple serovars. The serovars identified by the MAT with the greatest frequency were from the Icterohaemorrhagiae serogroup. Two rats had antibodies for serogroup Cynopteri, the first time this serogroup has been identified on Grenada.

CONCLUSIONS:

Our results for Leptospira exposure in rats in Grenada support R. norvegicus as an important reservoir host for Leptospira, particularly those from the Icterohaemorrhagiae serogroup. Because this serogroup is the primary serogroup responsible for documented human exposure in Grenada, exposed rats represent a public health threat.
Assuntos
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Ratos / Leptospira Limite: Animals País/Região como assunto: Caribe / Caribe ingles / Grenada Idioma: En Revista: West Indian med. j Assunto da revista: MEDICINA Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Granada País de publicação: Jamaica
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Ratos / Leptospira Limite: Animals País/Região como assunto: Caribe / Caribe ingles / Grenada Idioma: En Revista: West Indian med. j Assunto da revista: MEDICINA Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Granada País de publicação: Jamaica