Evaluation of simvastatin in the process of fracture healing in tibiae of rats
Rev. bras. ortop
; 48(2): 191-195, abr. 2013. graf
Artigo
em Inglês
| LILACS
| ID: lil-677016
Biblioteca responsável:
BR26.1
ABSTRACT
OBJECTIVE:
Evaluate the effects of simvastatin in the process of fracture healing in rat tibia.METHODS:
Thirty-six rats were subjected to diaphyseal fracture of the leg bones and divided in the statin group (GE) and control group (GC), being subdivided into three subgroups according to days post-fracture (7th, 14th and 28th day) to assess bone healing. In GE was administered by gavage a solution of simvastatin to the sacrifice. In the control group was administered saline by the same route of SG. Immobilization was not used. After the sacrifice was made to limb amputation in the distal femur and conducted the clinical, radiological and histological analysis. Clinical evaluation was made as to the mobility of the fracture. Then the samples were radiographed and evaluated for callus diameter. Histological examination was performed with cuts of 5 micrometers and stained with hematoxylin-eosin, Masson's trichrome and Alcian blue pH 2.5. The level of significance to exclude the null hypothesis was 5%.RESULTS:
All GE animals showed greater stability of the fracture and higher callus area. There were no significant changes in the histological study.CONCLUSION:
Simvastatin accelerates the consolidation process by increasing the callus, but does not alter the histology of the newly formed bone. .
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Fraturas da Tíbia
/
Consolidação da Fratura
/
Sinvastatina
Limite:
Animais
Idioma:
Inglês
Revista:
Rev. bras. ortop
Assunto da revista:
Ortopedia
Ano de publicação:
2013
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Federal do Maranhão/BR