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Increasing of syncytial knot and fibrinoid deposit in high-Cd accumulated human placentas / Aumento del nodo sincicial y depósitos de fibrinoide en placenta humanas con alta acumulación de cadmio
Phuapittayalert, Laorrat; Norkaew, Thongchai; Supanpaiboon, Wisa; Chuenchoojit, Supaporn; Hipkeao, Wiphawi; Swaddiwudhipong, Witaya; Sakulsak, Natthiya.
Afiliação
  • Phuapittayalert, Laorrat; Naresuan University. Faculty of Medical Science. Department of Anatomy. Phitsanulok. TH
  • Norkaew, Thongchai; Naresuan University. Faculty of Medical Science. Phitsanulok. TH
  • Supanpaiboon, Wisa; Naresuan University. Faculty of Medical Science. Department of Biochemistry. Phitsanulok. TH
  • Chuenchoojit, Supaporn; Burirum Rajabhat University. Faculty of Science. Division of Community Public Health. Burirum. TH
  • Hipkeao, Wiphawi; KhonKaen University. Faculty of Medicine. Department of Anatomy. KhonKaen. TH
  • Swaddiwudhipong, Witaya; Mae Sot General Hospital. Department of Community and Social Medicine. Tak. TH
  • Sakulsak, Natthiya; Naresuan University. Faculty of Medical Science. Department of Anatomy. Phitsanulok. TH
Int. j. morphol ; 31(4): 1210-1215, Dec. 2013. ilus
Artigo em Inglês | LILACS | ID: lil-702295
Biblioteca responsável: CL1.1
ABSTRACT
A toxic metal, cadmium (Cd), can accumulate in human organs. Placenta is usually used as indicator organ for Cd exposure. Therefore, we aim to investigate the different of placental morphology between the low- and high-Cd accumulated placentas. The samples were collected from 14 pregnant women who resided in low-Cd contaminated (L-Cd group) and high-Cd contaminated (H-Cd group) areas. The concentrations of Cd in blood (B-Cd), urine (U-Cd) and placentas (P-Cd) were measured by ICP-MS and AAS. The morphological appearance of placentas was examined by using routine paraffin section and H & E staining. The results showed that levels of B-Cd, U-Cd and P-Cd were significantly higher in H-Cd group than in L-Cd group (p= 0.001). Moreover, the B-Cd was positively correlated with U-Cd (rs= 0.823, p= 0.000) and P-Cd concentrations (rs= 0.854, p= 0.000). The appearances of syncytial knot (STK) and fibrinoid deposit (Fd) were obviously greater in H-Cd group than in L-Cd group (p= 0.007, p= 0.026). The STK was positively correlated with both Fd (rs= 0.572, p= 0.032) and P-Cd concentration (rs= 0.766, p= 0.001). Although the chorioamnitis and decidual inflammation features were found in both groups but the appearance in H-Cd group seems to be more severe than in L-Cd group. From these results, we suggested that high Cd level in placenta may be involved in morphological changes, especially STK and Fd increasing and probably disturb the connection between maternal and fetal circulation.
RESUMEN
Un metal tóxico, el cadmio (Cd), se puede acumular en órganos humanos. La placenta se utiliza, por lo general, como órgano indicador de la exposición a Cd. Nuestro objetivo fue investigar la diferente morfología placentaria entre las placentas con baja y alta acumulación de Cd. Las muestras fueron recolectadas de 14 mujeres embarazadas que residían áreas con alta (grupo H-Cd) y baja contaminación por Cd (grupo L-Cd). Las concentraciones de Cd en la sangre (B- Cd), orina (U-Cd) y placentas (P-Cd) se midieron por ICP-MS y AAS. La apariencia morfológica de las placentas fue examinada usando cortes histológicos teñidos con H-E. Los resultados mostraron que los niveles de B-Cd, U-Cd y P-Cd fueron significativamente mayores en el grupo H-Cd (p= 0,001). Por otra parte, el B-Cd se correlacionó positivamente con las concentraciones de U-Cd (rs= 0,854, p = 0,000 ) y P-Cd (rs= 0,823, p = 0,000). Las apariciones de nodos sinciciales (NS) y depósitos fibrinoides (Fd) fueron mayores en el grupo H-Cd (rs= 0,007, p= 0,026). Los ND se correlacionaron positivamente con los Fd (rs= 0,572, p= 0,032) y la concentración de P-Cd (rs= 0,766, p = 0,001). Aunque características de corioamnitis e inflamación de la decidua se encontraron en ambos grupos, su aparición en el grupo H-Cd pareció ser más grave que en el grupo L-Cd. A partir de estos resultados, sugerimos que el nivel alto de Cd en la placenta puede estar involucrado en los cambios morfológicos, especialmente el aumento de NS y Fd, los que probablemente alteran la relación entre la circulación materna y fetal.
Assuntos

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Placenta / Cádmio / Fibrina Limite: Feminino / Humanos / Gravidez Idioma: Inglês Revista: Int. j. morphol Assunto da revista: Anatomia Ano de publicação: 2013 Tipo de documento: Artigo País de afiliação: Tailândia Instituição/País de afiliação: Burirum Rajabhat University/TH / KhonKaen University/TH / Mae Sot General Hospital/TH / Naresuan University/TH

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Placenta / Cádmio / Fibrina Limite: Feminino / Humanos / Gravidez Idioma: Inglês Revista: Int. j. morphol Assunto da revista: Anatomia Ano de publicação: 2013 Tipo de documento: Artigo País de afiliação: Tailândia Instituição/País de afiliação: Burirum Rajabhat University/TH / KhonKaen University/TH / Mae Sot General Hospital/TH / Naresuan University/TH
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