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FASN expression, angiogenesis and lymphangiogenesis in central and peripheral giant cell lesions
FALCI, Saulo Gabriel Moreira; MESQUITA, Ana Terezinha Marques; ANDRADE, Bruno Augusto Benevenuto de; MIRANDA, Joao Luiz de; LEON, Jorge Esquiche; ALMEIDA, Oslei Paes de; SANTOS, Cassio Roberto Rocha dos.
Afiliação
  • FALCI, Saulo Gabriel Moreira; Federal University of Vales do Jequitinhonha e Mucuri. College of Basic Sciences and Health. Department of Dentistry. Diamantina. BR
  • MESQUITA, Ana Terezinha Marques; Federal University of Vales do Jequitinhonha e Mucuri. College of Basic Sciences and Health. Department of Dentistry. Diamantina. BR
  • ANDRADE, Bruno Augusto Benevenuto de; Federal University of Vales do Jequitinhonha e Mucuri. College of Basic Sciences and Health. Department of Dentistry. Diamantina. BR
  • MIRANDA, Joao Luiz de; Federal University of Vales do Jequitinhonha e Mucuri. College of Basic Sciences and Health. Department of Dentistry. Diamantina. BR
  • LEON, Jorge Esquiche; Federal University of Vales do Jequitinhonha e Mucuri. College of Basic Sciences and Health. Department of Dentistry. Diamantina. BR
  • ALMEIDA, Oslei Paes de; Federal University of Vales do Jequitinhonha e Mucuri. College of Basic Sciences and Health. Department of Dentistry. Diamantina. BR
  • SANTOS, Cassio Roberto Rocha dos; Federal University of Vales do Jequitinhonha e Mucuri. College of Basic Sciences and Health. Department of Dentistry. Diamantina. BR
J. appl. oral sci ; 22(2): 131-137, Mar-Apr/2014. tab, graf
Artigo em Inglês | LILACS | ID: lil-704194
Biblioteca responsável: BR1.1
ABSTRACT
Central giant cell lesion (CGCL) and peripheral giant cell lesion (PGCL) are non-neoplastic proliferative processes of the jaws. PGCL is a reactive process induced by irritant local factors and CGCL is an intra-osseous lesion of unknown etiology. Both lesions exhibit similar histologic features showing abundant mononuclear cells, admixed with a large number of multinucleated giant cells and a rich vascularized stroma with extravasated erythrocytes, hemosiderin deposition, and blood-filled pools. Recent studies have linked fatty acid synthase (FASN) with angiogenesis.

Objective:

To evaluate angiogenesis and lymphangiogenesis and their relationship with FASN expression in CGCL and PGCL. Material and

Methods:

Thirteen CGCL and 14 PGCL of the jaws were selected for immunoexpression of FASN; CD34 and CD105 (to assess blood microvessel density [MVD] and microvessel area [MVA]); and D2-40 (to assess lymphatic MVD and MVA).

Results:

Within PGCL and CGCL, MVD-CD34 was signifcantly higher than MVD-CD10S, followed by MVD-D2-40. Moreover, a signifcantly higher number of FASN-positive multinucleated giant cells than mononuclear cells were observed. Between PGCL and CGCL, only MVD-CD34 and all MVA were signifcantly higher in PGCL. Positive correlation between MVA-CD10S with FASNpositive mononuclear cells in both lesions was observed.

Conclusions:

Our results show both lesions exhibiting similar levels of FASN expression and neoangiogenesis, suggesting constitutive processes that regulate tissue maintenance. .
Assuntos

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Doenças Maxilomandibulares / Células Gigantes / Linfangiogênese / Ácido Graxo Sintase Tipo I / Neovascularização Patológica Tipo de estudo: Estudo de avaliação Limite: Adolescente / Adulto / Feminino / Humanos / Masculino Idioma: Inglês Revista: J. appl. oral sci Assunto da revista: Odontologia Ano de publicação: 2014 Tipo de documento: Artigo / Documento de projeto País de afiliação: Brasil Instituição/País de afiliação: Federal University of Vales do Jequitinhonha e Mucuri/BR

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Doenças Maxilomandibulares / Células Gigantes / Linfangiogênese / Ácido Graxo Sintase Tipo I / Neovascularização Patológica Tipo de estudo: Estudo de avaliação Limite: Adolescente / Adulto / Feminino / Humanos / Masculino Idioma: Inglês Revista: J. appl. oral sci Assunto da revista: Odontologia Ano de publicação: 2014 Tipo de documento: Artigo / Documento de projeto País de afiliação: Brasil Instituição/País de afiliação: Federal University of Vales do Jequitinhonha e Mucuri/BR
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