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Effects of R219K polymorphism of ATP-binding cassette transporter 1 gene on serum lipids ratios induced by a high-carbohydrate and low-fat diet in healthy youth
Liu, Hui; Lin, Jia; Zhu, Xing Chun; Li, Yuan Hao; Fan, Mei; Zhang, Rong Rong; Fang, Ding Zhi.
Afiliação
  • Liu, Hui; Sichuan University. West China School of Preclinical and Forensic Medicine. Department of Biochemistry and Molecular Biology. Chengdu. CN
  • Lin, Jia; Sichuan University. West China School of Preclinical and Forensic Medicine. Department of Biochemistry and Molecular Biology. Chengdu. CN
  • Zhu, Xing Chun; Sichuan University. West China School of Preclinical and Forensic Medicine. Department of Biochemistry and Molecular Biology. Chengdu. CN
  • Li, Yuan Hao; Sichuan University. West China School of Preclinical and Forensic Medicine. Department of Biochemistry and Molecular Biology. Chengdu. CN
  • Fan, Mei; Sichuan University. West China School of Preclinical and Forensic Medicine. Department of Biochemistry and Molecular Biology. Chengdu. CN
  • Zhang, Rong Rong; Sichuan University. West China School of Preclinical and Forensic Medicine. Department of Biochemistry and Molecular Biology. Chengdu. CN
  • Fang, Ding Zhi; Sichuan University. West China School of Preclinical and Forensic Medicine. Department of Biochemistry and Molecular Biology. Chengdu. CN
Biol. Res ; 47: 1-6, 2014. tab
Artigo em Inglês | LILACS | ID: lil-710927
Biblioteca responsável: CL1.1
ABSTRACT

BACKGROUND:

Diets are the important players in regulating plasma lipid profiles. And the R219K polymorphism at the gene of ATP-binding cassette transporter 1(ABCA1) was reported to be associated with the profiles. However, no efforts have been made to investigate the changes of lipid profiles after a high-carbohydrate and low-fat diet in different subjects with different genotypes of this polymorphism. This study was to evaluate the effects of ABCA1 R219K polymorphism on serum lipid and apolipoprotein (apo) ratios induced by a high-carbohydrate/low-fat (high-CHO) diet. After a washout diet of 54.1% carbohydrate for 7 days, 56 healthy young subjects (22.89 ± 1.80 years old) were given a high-CHO diet of 70.1% carbohydrate for 6 days. Height, weight, waist circumference, hip circumference, glucose (Glu), triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apoA-1 and apoB-100 were measured on the 1st, 8th and 14th days of this study. Body mass index (BMI), waist-to-hip ratios (WHR), log(TG/HDL-C), TC/HDL-C, LDL-C/HDL-C and apoA-1/apoB-100 were calculated. ABCA1 R219K was analyzed by a PCR-RFLP method.

RESULTS:

The results indicate that the male subjects of all the genotypes had higher WHR than their female counterparts on the 1st, 8th and 14th days of this study. The male K carriers had higher log(TG/HDL-C) and TC/HDL-C than the female carriers on the 1st and 14th days, and higher LDL-C/HDL-C on the 14th day. When compared with that on the 8th day, TC/HDL-C was decreased regardless of the genotypes and genders on the 14th day. Log(TG/HDL-C) was increased in the males with the RR genotype and the female K carriers. Lowered BMI, Glu and LDL-C/HDL-C were found in the male K carriers, but only lowered BMI in the female K carriers and only lowered LDL-C/HDL-C in the females with the RR genotype.

CONCLUSIONS:

These results suggest that ABCA1 R219K polymorphism is associated differently in males and females with elevated log(TG/HDL-C) and decreased LDL-C/HDL-C induced by the high-CHO diet.
Assuntos


Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Apolipoproteínas / Polimorfismo Genético / Carboidratos da Dieta / Colesterol / Dieta com Restrição de Gorduras / Transportadores de Cassetes de Ligação de ATP Limite: Adulto / Feminino / Humanos / Masculino Idioma: Inglês Revista: Biol. Res Assunto da revista: Biologia Ano de publicação: 2014 Tipo de documento: Artigo / Documento de projeto País de afiliação: China Instituição/País de afiliação: Sichuan University/CN

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Apolipoproteínas / Polimorfismo Genético / Carboidratos da Dieta / Colesterol / Dieta com Restrição de Gorduras / Transportadores de Cassetes de Ligação de ATP Limite: Adulto / Feminino / Humanos / Masculino Idioma: Inglês Revista: Biol. Res Assunto da revista: Biologia Ano de publicação: 2014 Tipo de documento: Artigo / Documento de projeto País de afiliação: China Instituição/País de afiliação: Sichuan University/CN
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