Effect of vitamin K1 supplementation on left colon healing in rats with extrahepatic biliary obstruction
Acta cir. bras
; Acta cir. bras;29(8): 522-527, 08/2014. tab, graf
Article
em En
| LILACS
| ID: lil-719187
Biblioteca responsável:
BR1.1
ABSTRACT
PURPOSE:
To evaluate the effects of vitamin K1 on wound healing in the left colon of rats with experimental biliary obstruction.METHODS:
Sixteen male rats, divided into four groups of four animals each (L, M, LK, and MK), underwent colostomy followed by bowel suture in the left colon. Seven days before, animals in the L and LK groups had undergone common bile duct ligation. The animals in groups MK and LK received vitamin K1 supplementation. On day 7 after bowel suture, repeat laparotomy was performed for evaluation of colonic healing by burst pressure measurement and collection of samples for histopathological analysis. Changes in body weight were evaluated in the four groups.RESULTS:
Weight loss was lower in animals supplemented with vitamin K. No significant differences were observed in burst pressure among the four groups (p>0.05). Histological analysis showed more hemorrhage and congestion in the biliary obstruction groups. Supplemented animals exhibited increased collagen formation and less edema and abscess formation.CONCLUSION:
Vitamin K supplementation attenuated weight loss and improved colonic wound healing in rats. .Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Vitamina K 1
/
Cicatrização
/
Colestase Extra-Hepática
/
Colo
/
Ducto Colédoco
/
Suplementos Nutricionais
Limite:
Animals
Idioma:
En
Revista:
Acta cir. bras
Assunto da revista:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil