Histological modification in TRAM flap in rats treated with pentoxifylline
Acta cir. bras
; 29(supl.2): 34-37, 2014. graf
Artigo
em Inglês
| LILACS
| ID: lil-721385
Biblioteca responsável:
BR1.1
ABSTRACT
PURPOSE:
To investigate the blood vessels' concentration in TRAM flap's rat model, in the presence of pentoxifylline.METHODS:
32 male, Wistar-EPM rats were divided into two groups. Control group (C) 0.5 ml of saline, intraperitoneally, once a day, for seven days before flap elevation; PTX group (P) pentoxifylline (20mg/kg/day), intraperitoneally, for seven days before flap elevation. After that, they were submitted to a caudal unipedicle TRAM flap. On the fifth postoperative day, percentages of flap necrosis were determined via the "paper template" method and Tram flap's zone IV skin biopsies were taken for histological analysis.RESULTS:
the mean percentage of flap necrosis in group C was 58.7 % and in group P, 31.1 (Wilcoxon test; p = 0.003). Mean capillary vessels number in zone IV's skin in C group was 33.4 and in P group was 71.9 (p=0.008).CONCLUSIONS:
Pentoxifylline was effective reducing the necrosis in the caudal unipedicle TRAM flap in the rat as well as increasing the number of capillaries in an ischemic zone (zone IV). .
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Pentoxifilina
/
Retalhos Cirúrgicos
/
Sobrevivência de Tecidos
/
Capilares
/
Inibidores da Agregação Plaquetária
/
Reto do Abdome
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Acta cir. bras
Assunto da revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2014
Tipo de documento:
Artigo
País de afiliação:
Brasil