Non-Hodgkins Lymphoma: Five-year Survival in a Historical Cohort of Patients who Underwent Stem Cell Transplantationin Brazil / Linfoma No-Hodgkin: Supervivencia de Cinco Años en una Cohorte Histórica dePacientes Sometidos a Trasplante de Células Madre en Brasil / Linfoma Não-Hodgkin: Sobrevida de Cinco Anos em uma Coorte Histórica dePacientes Submetidos a Transplante de Células-Tronco no Brasil
Rev. bras. cancerol
; 60(1): 35-42, jan.-mar. 2014. tab, graf
Artigo
em Inglês
| LILACS
| ID: lil-726080
Biblioteca responsável:
BR440.3
ABSTRACT
Introduction:
Several studies have shown the benefits of stem cell transplantation in the treatment of Non-Hodgkins lymphoma.Objective:
To evaluate survival and associated factors in transplanted Non-Hodgkins lymphoma patients in Brazil.Method:
We conducted a retrospective analysis of 100 adult patients with Non-Hodgkins lymphoma transplanted in a national reference center for hematopoietic stem cell transplantation between 1997 and 2009. Data was obtained from medical charts and included besides socio-demographic and lifestyle variables, others relatedto diagnosis and transplantation. The five-year survival probability was estimated using the Kaplan-Meier method and differences between curves were tested with the log-rank test, assuming statistical significance level of 5%. Cox regression was performed for multivariate analysis.Results:
Median age at diagnosis was 43 years (17-65) and 45 years (18-66) at transplantation. Median time between diagnosis and transplantation was 17 months (4-173). The probability of survival at 5 years was 50.8% with a median survival time of 22.5 months. In multivariate analysis, evidence of disease 12 months after transplant (HR 4.49; 95% CI 2.15-9.39), chemo-sensitivity to the last regimenbefore transplant (HR 2.92; 95% CI 1.35-6.32) and advanced stage at diagnosis (HR 1.96, 95% CI 1.02-3.80)were prognostic factors for survival.Conclusion:
Median age at transplantation in this cohort was similar to that of other studies but median time between diagnosis and transplantation was higher. Although overall survival (5 years) approached that reported in other studies, different treatment protocols and specific characteristics of each populationlimit comparisons
Analise de Sobrevida; Analísis de Supervivencia; Brasil; Brasil; Instituciones Oncológicas; Instituto do Câncer; Linfoma no Hodgkin; Linfoma não Hodgkin; Tasa de Supervivencia; Taxa de Sobrevida; Transplante de Células Madre; Transplantes de Células-Tronco; hematopoietic stem cell transplantation; lymphoma, non-Hodgkin; prognostic factor; survival
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Linfoma não Hodgkin
/
Brasil
/
Institutos de Câncer
/
Análise de Sobrevida
/
Taxa de Sobrevida
/
Transplante de Células-Tronco
Tipo de estudo:
Guia de prática clínica
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
Rev. bras. cancerol
Assunto da revista:
Neoplasias
Ano de publicação:
2014
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Center for Cancer Treatment-CENTRON/BR
/
Oswaldo Cruz Foundation/BR