Effects of vardenafil on the kidney of Wistar rats submitted to acute ischemia and reperfusion
Acta cir. bras
; 30(5): 339-344, 05/2015. tab, graf
Artigo
em Inglês
| LILACS
| ID: lil-747023
Biblioteca responsável:
BR1.1
ABSTRACT
PURPOSE:
To investigate the effect of vardenafil in kidney of rats submitted to acute ischemia and reperfusion.METHODS:
Twenty-eight rats were randomly distributed into two groups. Right nephrectomy was performed and the vardenafil group received vardenafil solution (at a concentration of 1 mg/ml in 10 mg/kg) while the control group received 0.9% saline solution (SS) one hour prior to the ligature of the left renal pedicle. After one hour of ischemia, animals were submitted to twenty-four hours of reperfusion, followed by left nephrectomy. The kidney's histological parameters evaluated on the study included vacuolar degeneration and tubular necrosis. Apoptosis was assessed by immunohistochemistry for cleaved caspase-3 using the point-counting and digital methods (Cytophotometry). Also, a biochemical analysis for creatinine was conducted.RESULTS:
There were statistically significant differences between groups only with regards to the vacuolar degeneration parameter and to the cleaved caspase-3 digital method.CONCLUSION:
Vardenafil showed a protective effect on the kidney of rats subjected to acute ischemia and reperfusion in this model .
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Doença Cardiovascular
/
Neoplasias do Rim, Pelve Renal e Ureteral
Base de dados:
LILACS
Assunto principal:
Piperazinas
/
Traumatismo por Reperfusão
/
Imidazóis
/
Isquemia
/
Rim
Tipo de estudo:
Estudo de avaliação
/
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Acta cir. bras
Assunto da revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2015
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Mogi das Cruzes University/BR