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Short-term follow-up of exercise training program and beta-blocker treatment on quality of life in dogs with naturally acquired chronic mitral valve disease
Marcondes-Santos, M.; Mansur, A.P.; Fragata, F.S.; Strunz, C.M.C..
Afiliação
  • Marcondes-Santos, M.; Hospital Veterinário Sena Madureira. São Paulo. BR
  • Mansur, A.P.; Hospital Veterinário Sena Madureira. São Paulo. BR
  • Fragata, F.S.; Hospital Veterinário Sena Madureira. São Paulo. BR
  • Strunz, C.M.C.; Hospital Veterinário Sena Madureira. São Paulo. BR
Braz. j. med. biol. res ; 48(10): 886-894, Oct. 2015. tab, ilus
Artigo em Inglês | LILACS | ID: lil-761604
Biblioteca responsável: BR1.1
ABSTRACT
This study aimed to evaluate the effects of carvedilol treatment and a regimen of supervised aerobic exercise training on quality of life and other clinical, echocardiographic, and biochemical variables in a group of client-owned dogs with chronic mitral valve disease (CMVD). Ten healthy dogs (control) and 36 CMVD dogs were studied, with the latter group divided into 3 subgroups. In addition to conventional treatment (benazepril, 0.3-0.5 mg/kg once a day, and digoxin, 0.0055 mg/kg twice daily), 13 dogs received exercise training (subgroup I; 10.3±2.1 years), 10 dogs received carvedilol (0.3 mg/kg twice daily) and exercise training (subgroup II; 10.8±1.7 years), and 13 dogs received only carvedilol (subgroup III; 10.9±2.1 years). All drugs were administered orally. Clinical, laboratory, and Doppler echocardiographic variables were evaluated at baseline and after 3 and 6 months. Exercise training was conducted from months 3-6. The mean speed rate during training increased for both subgroups I and II (ANOVA, P>0.001), indicating improvement in physical conditioning at the end of the exercise period. Quality of life and functional class was improved for all subgroups at the end of the study. The N-terminal pro-brain natriuretic peptide (NT-proBNP) level increased in subgroup I from baseline to 3 months, but remained stable after training introduction (from 3 to 6 months). For subgroups II and III, NT-proBNP levels remained stable during the entire study. No difference was observed for the other variables between the three evaluation periods. The combination of carvedilol or exercise training with conventional treatment in CMVD dogs led to improvements in quality of life and functional class. Therefore, light walking in CMVD dogs must be encouraged.
Assuntos

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Condicionamento Físico Animal / Propanolaminas / Qualidade de Vida / Carbazóis / Antagonistas Adrenérgicos beta / Insuficiência da Valva Mitral Limite: Animais Idioma: Inglês Revista: Braz. j. med. biol. res Assunto da revista: Biologia / Medicina Ano de publicação: 2015 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Hospital Veterinário Sena Madureira/BR

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Condicionamento Físico Animal / Propanolaminas / Qualidade de Vida / Carbazóis / Antagonistas Adrenérgicos beta / Insuficiência da Valva Mitral Limite: Animais Idioma: Inglês Revista: Braz. j. med. biol. res Assunto da revista: Biologia / Medicina Ano de publicação: 2015 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Hospital Veterinário Sena Madureira/BR
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