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Left ventricular hypertrophy in children, adolescents and young adults with sickle cell anemia
Faro, Gustavo Baptista de Almeida; Menezes-Neto, Osvaldo Alves; Batista, Geodete Santos; Silva Neto, Antônio Pereira; Cipolotti, Rosana.
Afiliação
  • Faro, Gustavo Baptista de Almeida; Universidade Federal de Sergipe. Aracaju. BR
  • Menezes-Neto, Osvaldo Alves; Universidade Federal de Sergipe. Aracaju. BR
  • Batista, Geodete Santos; Universidade Federal de Sergipe. Aracaju. BR
  • Silva Neto, Antônio Pereira; Universidade Federal de Sergipe. Aracaju. BR
  • Cipolotti, Rosana; Universidade Federal de Sergipe. Aracaju. BR
Rev. bras. hematol. hemoter ; 37(5): 324-328, Sept.-Oct. 2015. tab
Artigo em Inglês | LILACS | ID: lil-764222
Biblioteca responsável: BR408.1
Localização: BR408.1
ABSTRACT

OBJECTIVE:

The aims of this study were to estimate the frequency of left ventricular hypertrophy and to identify variables associated with this condition in under 25-year-old patients with sickle cell anemia.

METHODS:

A cross-sectional study was performed of children, adolescents and young adults with sickle cell anemia submitted to a transthoracic Doppler echocardiography. The mass of the left ventricle was determined by the formula of Devereux et al. with correction for height, and the percentile curves of gender and age were applied. Individuals with rheumatic and congenital heart disease were excluded. The patients were divided into two groups according to the presence or absence of left ventricular hypertrophy and compared according to clinical, echocardiographic and laboratory variables.

RESULTS:

A total of 37.6% of the patients had left ventricular hypertrophy in this sample. There was no difference between the groups of patients with and without hypertrophy according to pathological history or clinical characteristics, except possibly for the use of hydroxyurea, more often used in the group without left ventricular hypertrophy. Patients with left ventricular hypertrophy presented larger left atria and lower hemoglobin and hematocrit levels, reticulocyte index and a higher albumincreatinine ratio in urine.

CONCLUSION:

Left ventricular hypertrophy was observed in more than one-third of the young patients with sickle cell anemia with this finding being inversely correlated to the hemoglobin and hematocrit levels, and reticulocyte index and directly associated to a higher albumin/creatinine ratio. It is possible that hydroxyurea had had a protective effect on the development of left ventricular hypertrophy.
Assuntos

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Ecocardiografia / Função Ventricular Esquerda / Disfunção Ventricular Esquerda / Anemia Falciforme Limite: Feminino / Humanos / Masculino Idioma: Inglês Revista: Rev. bras. hematol. hemoter Assunto da revista: Hematologia Ano de publicação: 2015 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Universidade Federal de Sergipe/BR

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Ecocardiografia / Função Ventricular Esquerda / Disfunção Ventricular Esquerda / Anemia Falciforme Limite: Feminino / Humanos / Masculino Idioma: Inglês Revista: Rev. bras. hematol. hemoter Assunto da revista: Hematologia Ano de publicação: 2015 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Universidade Federal de Sergipe/BR
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