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Musanga cecropioides leaf extract exhibits anti-inflammatory and anti-nociceptive activities in animal models
Sowemimo, Abimbola; Okwuchuku, Eboji; Samuel, Fageyinbo Muyiwa; Ayoola, Olowokudejo; Mutiat, Ibrahim.
Afiliação
  • Sowemimo, Abimbola; University of Lagos. Faculty of Pharmacy. Department of Pharmacognosy. Lagos. NG
  • Okwuchuku, Eboji; University of Lagos. Faculty of Pharmacy. Department of Pharmacognosy. Lagos. NG
  • Samuel, Fageyinbo Muyiwa; University of Lagos. Faculty of Pharmacy. Department of Pharmacognosy. Lagos. NG
  • Ayoola, Olowokudejo; University of Lagos. Faculty of Pharmacy. Department of Pharmacognosy. Lagos. NG
  • Mutiat, Ibrahim; University of Lagos. Faculty of Pharmacy. Department of Pharmacognosy. Lagos. NG
Rev. bras. farmacogn ; 25(5): 506-512, Sept.-Oct. 2015. tab, graf
Artigo em Inglês | LILACS-Express | LILACS | ID: lil-765073
Biblioteca responsável: BR1.1
ABSTRACT
ABSTRACTExtract obtained from the leaves of Musanga cecropioides R. Br. ex Tedlie, Urticaceae, a tree growing in Africa, is used traditionally in the treatment of edema and rheumatism. The anti-inflammatory and anti-nociceptive properties of ethanol extract were studied using the carrageenan, histamine, serotonin and xylene-induced edema tests as well as the formalin, mouse writhing and tail clip tests. Significant dose dependent inhibition was observed in the carrageenan model with peak inhibition at 150 mg/kg (71.43%, 90 min, p < 0.001). In the histamine and serotonin models, the extract caused significant inhibition of 83.33% (p < 0.05) and 45% (p < 0.01) at 120 min respectively. For the xylene model, the extract showed maximum inhibition (59.25%) at 200 mg/kg. Also, M. cecropioides produced significant anti-nociceptive activity in the mouse writhing (55.12%, p < 0.01), formalin (81.88%, p < 0.01) and tail clip (11.78%, p< 0.001) tests at 200 mg/kg respectively. The results obtained in this study demonstrated that the ethanolic leaf extract of M. cecropioidespossesses anti-inflammatory effect possibly mediated via histaminergic and serotonergic inhibition and anti-nociceptive effect mediated via peripheral mechanism with mild central involvement.

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Idioma: Inglês Revista: Rev. bras. farmacogn Assunto da revista: Farmácia Ano de publicação: 2015 Tipo de documento: Artigo País de afiliação: Nigéria Instituição/País de afiliação: University of Lagos/NG

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Idioma: Inglês Revista: Rev. bras. farmacogn Assunto da revista: Farmácia Ano de publicação: 2015 Tipo de documento: Artigo País de afiliação: Nigéria Instituição/País de afiliação: University of Lagos/NG
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