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Evaluation of peritoneal endometriosis treatment using intralesional acetylsalicylic acid injection in rabbits
Saad-Hossne, Rogério; Barretto, Adriana Beatriz; Siqueira, Juliana Menezes; Denadai, Rafael.
Afiliação
  • Saad-Hossne, Rogério; Universidade Estadual de São Paulo. Botucatu Medical School. Botucatu. BR
  • Barretto, Adriana Beatriz; Universidade Estadual de São Paulo. Botucatu Medical School. Botucatu. BR
  • Siqueira, Juliana Menezes; Universidade Estadual de São Paulo. Botucatu Medical School. Botucatu. BR
  • Denadai, Rafael; Universidade Estadual de São Paulo. Botucatu Medical School. Botucatu. BR
Acta cir. bras ; 31(4): 227-234, Apr. 2016. tab, graf
Article em En | LILACS | ID: lil-781325
Biblioteca responsável: BR1.1
ABSTRACT

PURPOSE:

To investigate the efficacy of intralesional 20% aspirin injection for treatment of experimental peritoneal endometriosis.

Methods:

Peritoneal endometriosis was experimentally induced in forty adult nulligravid female rabbits. On day 30 post-endometriosis induction, rabbits were randomly divided to assess early (10 days) and late (20 days) effects of intralesional injection of physiological saline solution (control groups) in comparison to intralesional injection of 20% bicarbonate aspirin solution (experimental groups) as follows control group 1 (10 days, n=10); control group 2 (20 days, n=10); experimental group 3 (10 days, n=10); experimental group 4 (20 days, n=10). Resected tissues, including endometriosis foci, were qualitatively (general morphology and signs of inflammatory cells infiltrate, necrosis and apoptosis) and quantitatively (remaining endometriosis area) assessed by histopathological analysis.

Results:

Extensive necrosis, hemorrhage, apoptosis, and fibrosis were observed in the experimental groups 3 and 4. Groups 1 and 2 presented typical endometrial tissue cysts, respectively. Groups 3 and 4 showed sparse endometrial tissue foci and no endometrial tissue, respectively. Quantitative analysis revealed that aspirin-treated groups 3 and 4 had significantly (p<0.05) smaller remaining endometriosis area, compared to control groups 1 and 2.

Conclusion:

Intralesional 20% aspirin injection caused total destruction of peritoneal endometriosis foci in rabbits.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Doenças Peritoneais / Injeções Intralesionais / Aspirina / Inibidores de Ciclo-Oxigenase / Endometriose Tipo de estudo: Evaluation_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Acta cir. bras Assunto da revista: CIRURGIA GERAL / Procedimentos Cir£rgicos Operat¢rios Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Doenças Peritoneais / Injeções Intralesionais / Aspirina / Inibidores de Ciclo-Oxigenase / Endometriose Tipo de estudo: Evaluation_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Acta cir. bras Assunto da revista: CIRURGIA GERAL / Procedimentos Cir£rgicos Operat¢rios Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil