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Effect of aqueous extract of the Vigna angularis in rats subjected to an experimental model of moderate chronic kidney disease
Baracho, Nilo César do Vale; Monteiro, Natália Fechus; Borges, Manuela Guedes; Arguelho, Raíssa Robles de Moura.
Afiliação
  • Baracho, Nilo César do Vale; Medical School of Itajubá. BR
  • Monteiro, Natália Fechus; Medical School of Itajubá. BR
  • Borges, Manuela Guedes; Medical School of Itajubá. BR
  • Arguelho, Raíssa Robles de Moura; Medical School of Itajubá. BR
Acta cir. bras ; 31(8): 527-532, Aug. 2016. graf
Artigo em Inglês | LILACS | ID: lil-792410
Biblioteca responsável: BR1.1
ABSTRACT
ABSTRACT

PURPOSE:

To evaluate the effect of the aqueous extract of the Vigna angularis, popularly known as "Azuki beans", in rats subjected to an experimental model of moderate chronic kidney disease.

METHODS:

Thirty rats underwent two surgeries - Ormrod and Miller (1980) - to obtain Moderate Chronic Kidney Disease (CKD-M). The animals were randomized into 3 groups. Group 1 (Control) distilled water. Group 2 (Azuki) Vigna angularis 5% aqueous extract. Group 3 (Treatment) 10mg/kg of enalapril maleate. The rats received their respective treatments for 14 days.

RESULTS:

The treatment with azuki beans produced an increase in urine output from the second day until the end of the experiment compared to the Control groups (p<0.01) and Treatment (p<0.05). The treatment with azuki also produced significant reductions in the levels of glucose, triglycerides, VLDL, uric acid, Alanine aminotransferase (p<0.05), urea and serum creatinine (p<0.01), besides having produced a significant increase in the levels of HDL when compared to the Control group.

CONCLUSION:

Treatment with Azuki beans produced improvements in the parameters of renal function and significantly reduced glucose levels, triglycerides, VLDL, alanine aminostransferase, uric acid and creatinine, besides having produced a significant increase in the levels of HDL in rats submitted to a model of moderate chronic kidney disease.
Assuntos

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Extratos Vegetais / Insuficiência Renal Crônica / Vigna / Fitoterapia Limite: Animais Idioma: Inglês Revista: Acta cir. bras Assunto da revista: CIRURGIA GERAL Ano de publicação: 2016 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Medical School of Itajubá/BR

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Extratos Vegetais / Insuficiência Renal Crônica / Vigna / Fitoterapia Limite: Animais Idioma: Inglês Revista: Acta cir. bras Assunto da revista: CIRURGIA GERAL Ano de publicação: 2016 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Medical School of Itajubá/BR
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