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Serum IgG antibody responses to pertussis toxin and filamentous hemagglutinin in nonvaccinated and vaccinated children and adults with pertussis.
Trollfors, B; Taranger, J; Lagergård, T; Sundh, V; Bryla, D A; Schneerson, R; Robbins, J B.
Afiliação
  • Trollfors B; Department of Pediatrics, Göteborg University, Sweden.
Clin Infect Dis ; 28(3): 552-9, 1999 Mar.
Article em En | MEDLINE | ID: mdl-10194077
ABSTRACT
Levels of IgG antibody to pertussis toxin (PT) and filamentous hemagglutinin (FHA) were measured in paired serum samples from 781 patients fulfilling at least one laboratory criterion for pertussis that was suggested by an ad hoc committee sponsored by the World Health Organization. The patients were participants or family members of participants in a double-blind efficacy trial of a monocomponent pertussis toxoid vaccine. Of 596 nonvaccinated children, 90% had significant (two-fold or more) rises in PT IgG and FHA IgG levels. Only 17 (32%) of 53 children previously vaccinated with three doses of pertussis toxoid had rises in PT IgG levels because they already had elevated PT IgG levels in their acute-phase serum samples. PT IgG and FHA IgG levels were significantly higher in acute-phase serum samples from 29 adults than in acute-phase serum samples from the nonvaccinated children. Nevertheless, significant rises in levels of PT IgG (79% of samples) and FHA IgG (90%) were demonstrated in adults. In conclusion, assay of PT IgG and FHA IgG in paired serum samples is highly sensitive for diagnosing pertussis in nonvaccinated individuals. Assay of PT IgG levels in paired sera is significantly less sensitive for diagnosis of pertussis for children vaccinated with pertussis toxoid.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Virulência de Bordetella / Imunoglobulina G / Vacina contra Coqueluche / Coqueluche / Adesinas Bacterianas / Toxina Pertussis / Hemaglutininas / Anticorpos Antibacterianos Tipo de estudo: Clinical_trials Limite: Adult / Humans / Infant Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 1999 Tipo de documento: Article País de afiliação: Suécia
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Virulência de Bordetella / Imunoglobulina G / Vacina contra Coqueluche / Coqueluche / Adesinas Bacterianas / Toxina Pertussis / Hemaglutininas / Anticorpos Antibacterianos Tipo de estudo: Clinical_trials Limite: Adult / Humans / Infant Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 1999 Tipo de documento: Article País de afiliação: Suécia