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5-Fluorouracil (5-FU), methyl-CCNU, and vincristine in the treatment of advanced colorectal cancer: phase II study utilizing weekly 5-FU.
Cancer Treat Rep ; 60(11): 1597-600, 1976 Nov.
Article em En | MEDLINE | ID: mdl-1021233
We report a phase II trial of 5-fluorouracil (5-FU), methyl-CCNU, and vincristine (FMV) combination chemotherapy in advanced colorectal carcinoma. Ten of 25 patients (40%) achieved an objective tumor regression after treatment with FMV chemotherapy. The main toxicities of FMV were hematologic and gastrointestinal. 5-FU was administered in a weekly rather than a loading-dose schedule which allowed for sensitive adjustment of drug dosages according to hematologic toxicity; only 16% of the patients (four of 25) had a wbc count less than 2000 cells/mm3. FMV is significantly more active than 5-FU alone in the treatment of advanced colorectal cancer; however this regimen does not significantly improve survival in responding patients.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Retais / Semustina / Vincristina / Neoplasias do Colo / Fluoruracila / Compostos de Nitrosoureia Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Treat Rep Ano de publicação: 1976 Tipo de documento: Article País de publicação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Retais / Semustina / Vincristina / Neoplasias do Colo / Fluoruracila / Compostos de Nitrosoureia Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Treat Rep Ano de publicação: 1976 Tipo de documento: Article País de publicação: Estados Unidos