Salivary glands of the sand fly Phlebotomus papatasi contain pharmacologically active amounts of adenosine and 5'-AMP.
J Exp Biol
; 202(Pt 11): 1551-9, 1999 Jun.
Article
em En
| MEDLINE
| ID: mdl-10229701
ABSTRACT
Salivary gland homogenates of the sand fly Phlebotomus papatasi contain large amounts of adenosine and 5'-AMP, of the order of 1 nmol per pair of glands, as demonstrated by liquid chromatography, ultraviolet spectrometry, mass spectrometry and bioassays. These purines, 75-80 % of which are secreted from the glands following a blood meal, have vasodilatory and anti-platelet activities and probably help the fly to obtain a blood meal. Salivary 5'-AMP is also responsible for the previously reported protein phosphatase inhibitor in the salivary glands of P. papatasi, which is shown to be artifactual in nature as a result of allosteric modification by AMP of the phosphatase substrate used (phosphorylase a).
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Base de dados:
MEDLINE
Assunto principal:
Phlebotomus
/
Glândulas Salivares
/
Adenosina
/
Monofosfato de Adenosina
Limite:
Animals
Idioma:
En
Revista:
J Exp Biol
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Estados Unidos