Red cell deformability, splenic function and anaemia in thalassaemia.
Br J Haematol
; 105(2): 505-8, 1999 May.
Article
em En
| MEDLINE
| ID: mdl-10233428
ABSTRACT
Red cell deformability (RCD) was measured in 38 patients with alpha-thalassaemia and 48 patients with beta-thalassaemia, of whom 13 had undergone splenectomy. All splenectomized patients, but none of those with intact spleens, had very rigid erythrocytes with an elongation index <0.45 at a high shear stress of 30 Pa suggesting a splenic recognition threshold for removal of rigid red cells. At this shear stress RCD correlated strongly with the degree of anaemia in both the splenectomized (r = 0.81, P < 0.001) and non-splenectomized beta-thalassaemic patients (all patients r = 0.81, P < 0.001; homozygous beta-thalassaemic patients r = 0.51, P = 0. 01). These data suggest that reduced RCD is a major determinant of anaemia in thalassaemia.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esplenopatias
/
Talassemia beta
/
Talassemia alfa
/
Deformação Eritrocítica
/
Anemia
Limite:
Humans
Idioma:
En
Revista:
Br J Haematol
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Holanda