[Importance of estimated value of T-cell activation in insulin-dependent diabetes mellitus]. / Znachimost' raschetnogo pokazatelia T-kletochnoi aktivatsii pri insulinzavisimom sakharnom diabete.

ABSTRACT

AIM: To determine the role of estimated value HLA-DR+/CD19+ in patients with insulin-dependent diabetes mellitus (IDDM) in the course of the disease. MATERIALS AND METHODS: The number of CD+ and HLA-DR+ lymphocytes and the ratio HLA-DR+/ CD19+ were estimated in the peripheral blood of 70 IDDM patients aged 9-47 years with the disease duration since the diagnosis 0-10. Indirect immunofluorescence with monoclonal antibodies was employed. RESULTS: The index HLA-DR+/CD19+ was normal in newly-diagnosed IDDM patients and tended to an increase with the disease aggravation. CONCLUSION: The index HLA-DR+/CD19+ can be used as an additional marker of T-lymphocyte activation, as a criterium of unfavorable IDDM course.