[Importance of estimated value of T-cell activation in insulin-dependent diabetes mellitus]. / Znachimost' raschetnogo pokazatelia T-kletochnoi aktivatsii pri insulinzavisimom sakharnom diabete.
Ter Arkh
; 71(4): 55-7, 1999.
Article
em Ru
| MEDLINE
| ID: mdl-10358866
ABSTRACT
AIM:
To determine the role of estimated value HLA-DR+/CD19+ in patients with insulin-dependent diabetes mellitus (IDDM) in the course of the disease. MATERIALS ANDMETHODS:
The number of CD+ and HLA-DR+ lymphocytes and the ratio HLA-DR+/ CD19+ were estimated in the peripheral blood of 70 IDDM patients aged 9-47 years with the disease duration since the diagnosis 0-10. Indirect immunofluorescence with monoclonal antibodies was employed.RESULTS:
The index HLA-DR+/CD19+ was normal in newly-diagnosed IDDM patients and tended to an increase with the disease aggravation.CONCLUSION:
The index HLA-DR+/CD19+ can be used as an additional marker of T-lymphocyte activation, as a criterium of unfavorable IDDM course.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ativação Linfocitária
/
Linfócitos T
/
Diabetes Mellitus Tipo 1
Limite:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Ru
Revista:
Ter Arkh
Ano de publicação:
1999
Tipo de documento:
Article