[Experimental study of residual virulence of viral vaccine strains]. / Eksperimental'noe izuchenie ostatochnoi virulentnosti shtammov virusa vaktsiny.
Vopr Virusol
; 44(2): 75-8, 1999.
Article
em Ru
| MEDLINE
| ID: mdl-10358902
ABSTRACT
Residual virulence of three vaccinia strains Neurovaccine, L-IVP, and its recombinant Revacs-B expressing HBs and preS2 antigens of hepatitis B virus is compared. Insertion of HBs and preS2 antigens of hepatitis B virus in the genome of vaccinia virus strain L-IVP decreases its residual virulence and leads to a benign course of vaccinal reaction involving no deaths of rabbits, cotton rats, or guinea pigs. We may expect that recombinant vaccine Revacs B based on L-IVP strain will cause no postvaccinal complications under conditions of an appreciable decrease in population immunity to vaccinia virus.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vaccinia virus
/
Vacinas Virais
Limite:
Animals
Idioma:
Ru
Revista:
Vopr Virusol
Ano de publicação:
1999
Tipo de documento:
Article