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A novel tablet-based 13C urea breath test for Helicobacter pylori with enhanced performance during acid suppression therapy.
Hamlet, A; Stage, L; Lönroth, H; Cahlin, C; Nyström, C; Pettersson, A.
Afiliação
  • Hamlet A; Dept. of Surgery, Sahlgren's University Hospital, Göteborg, Sweden.
Scand J Gastroenterol ; 34(4): 367-74, 1999 Apr.
Article em En | MEDLINE | ID: mdl-10365896
BACKGROUND: The urea breath test (UBT) can still be improved in terms of user-friendliness and accuracy during acid-suppression therapy. This study was designed to evaluate a novel, rapidly disintegrating 13C UBT tablet, which was supplemented with citric acid to facilitate diagnosis of Helicobacter pylori in the hypochlorhydric stomach. METHODS: The efficacy of a fasting 13C tablet-based UBT (TUBT) was compared with that of a standard 13C UBT (SUBT) during 40 min after dosing, and optimal sampling points were determined. The single-point TUBT was validated against a 'gold standard' (GS) including a TUBT, culture, histology, and a CLO test in 134 dyspeptic patients, and its optimal cut-off point was determined by means of a biometric method. In addition, 20 SUBT-positive patients were randomized to perform either the TUBT or the SUBT after 7 days of omeprazole therapy (20 mg twice daily). RESULTS: Compared with a SUBT, the TUBT gave a quicker and wider separation between positive and negative results and an earlier optimal sampling point (10 versus 40 min). At 10 min the TUBT correctly classified 40 of 42 GS-positive subjects (sensitivity, 95%) and all of 92 GS-negative patients (specificity, 100%), and the optimal cut-off point was 1.8 delta per mil. Furthermore, when optimal sampling points were used, the TUBT (t = 10 min) proved to be more accurate than the SUBT (t = 40 min) during omeprazole treatment, correctly identifying all of 10 and 3 of 9 H. pylori-infected patients, respectively. CONCLUSIONS: By supplying 13C urea and citric acid as a rapid-release tablet, it is possible to shorten the duration of the 13C UBT to 10 min, omit the test meal, and still maintain excellent accuracy, even during acid suppression therapy.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Testes Respiratórios / Helicobacter pylori / Infecções por Helicobacter / Dispepsia Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Scand J Gastroenterol Ano de publicação: 1999 Tipo de documento: Article País de afiliação: Suécia País de publicação: Reino Unido
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Testes Respiratórios / Helicobacter pylori / Infecções por Helicobacter / Dispepsia Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Scand J Gastroenterol Ano de publicação: 1999 Tipo de documento: Article País de afiliação: Suécia País de publicação: Reino Unido