Melatonin: from biochemistry to therapeutic applications.
Pol J Pharmacol
; 51(1): 3-23, 1999.
Article
em En
| MEDLINE
| ID: mdl-10389140
ABSTRACT
Melatonin (N-acetyl-5-methoxytryptamine) is an evolutionary highly conserved molecule that plays an important role in conveying the clock and calendar information to all living organisms, including man. The hormone is synthesized mainly by the pineal gland, and, to a lesser extent, by extrapineal tissues--such as the retina, Harderian gland, and gastrointestinal tract. The melatonin-generating system is characterized by three basic features (1) photosensitivity, (2) diurnal (or circadian) rhythmicity (with highest levels of the hormone production occurring at night in darkness), and (3) age-related decrease in its activity. This review surveys data on the regulation of rhythmic melatonin biosynthesis by an array of factors, such as circadian pacemaker, light, neurotransmitters, second and third messenger molecules. Recent developments in the field of melatonin receptors are also presented. Finally, physiological and therapeutic properties of melatonin, with a special emphasis given to possible applications of this compound in the treatment of circadian rhythm sleep disorders, are discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos do Sono-Vigília
/
Envelhecimento
/
Ritmo Circadiano
/
Melatonina
/
Antioxidantes
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Pol J Pharmacol
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Polônia