Decreased glomerular proteinase activity in the streptozotocin diabetic rat.
Am J Nephrol
; 19(3): 441-6, 1999.
Article
em En
| MEDLINE
| ID: mdl-10393385
ABSTRACT
Decreased glomerular proteinase activity may contribute to matrix accumulation in diabetes. Male Sprague-Dawley rats were rendered diabetic by injection of streptozotocin (STZ) 65 mg/kg i.v.; age-matched, sham-injected rats served as controls. Glomeruli from diabetic rats 1 month after STZ injection demonstrated significant decreases in collagenase and cathepsin B activities compared to control glomeruli. Treatment with insulin resulted in a slight (but not significant) increase in collagenase activity and normalized cathepsin B activity. We conclude that decreased glomerular collagenase and cathepsin B activities are present in STZ diabetes. These alterations may contribute to mesangial matrix accumulation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Catepsina B
/
Colagenases
/
Diabetes Mellitus Experimental
/
Glomérulos Renais
Limite:
Animals
Idioma:
En
Revista:
Am J Nephrol
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Estados Unidos
País de publicação:
CH
/
SUIZA
/
SUÍÇA
/
SWITZERLAND