Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo.
Nat Med
; 5(7): 810-6, 1999 Jul.
Article
em En
| MEDLINE
| ID: mdl-10395327
ABSTRACT
The mitogen-activated protein kinase pathway is thought to be essential in cellular growth and differentiation. Here we report the discovery of a highly potent and selective inhibitor of the upstream kinase MEK that is orally active. Tumor growth was inhibited as much as 80% in mice with colon carcinomas of both mouse and human origin after treatment with this inhibitor. Efficacy was achieved with a wide range of doses with no signs of toxicity, and correlated with a reduction in the levels of activated mitogen-activated protein kinase in excised tumors. These data indicate that MEK inhibitors represent a promising, noncytotoxic approach to the clinical management of colon cancer.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Benzamidas
/
Transdução de Sinais
/
Ciclo Celular
/
Neoplasias do Colo
/
Inibidores Enzimáticos
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Nat Med
Assunto da revista:
BIOLOGIA MOLECULAR
/
MEDICINA
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Estados Unidos