Fast excitatory post synaptic potentials and their response to catecholaminergic antagonists in rat sympathetic preganglionic neurones in vitro.
Neurosci Lett
; 268(2): 89-92, 1999 Jun 18.
Article
em En
| MEDLINE
| ID: mdl-10400085
ABSTRACT
In an in vitro slice preparation from neonatal rats intracellular recordings were made from electrophysiologically identified sympathetic preganglionic neurones. Electrical stimulation in the lateral funiculus (>500 microm) from the recording site elicited a mono- or polysynaptic excitatory post synaptic potential. The latter potential was blocked with the dopamine D2 antagonist haloperidol but not with the dopamine D1 antagonist SCH 23390. We therefore report the first showing of a functional descending pathway in an in vitro slice preparation describing both the transmitter and the receptor subtype involved and physiologically show that dopamine may exert an indirect excitatory influence on sympathetic preganglionic neurones possibly via interneurones present in the spinal cord.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fibras Autônomas Pré-Ganglionares
/
Sistema Nervoso Simpático
/
Catecolaminas
/
Potenciais Pós-Sinápticos Excitadores
/
Neurônios
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Reino Unido