Differences in adrenal steroid profile in chronic fatigue syndrome, in depression and in health.
J Affect Disord
; 54(1-2): 129-37, 1999 Jul.
Article
em En
| MEDLINE
| ID: mdl-10403156
ABSTRACT
BACKGROUND:
Hyperactivity and hypoactivity of the HPA have been forwarded as of pathophysiological relevance in major depressive disorder and chronic fatigue syndrome (CFS), respectively.METHODS:
This study examines cortisol levels in the two disorders, and also assesses levels of the adrenal androgens, dehydroepiandrosterone (DHEA) and its sulphate derivative (DHEA-S), and 17-alpha-hydroxyprogesterone; 15 subjects with CFS diagnosed according to CDC criteria, 15 subjects with DSM III-R major depression and 11 healthy subjects were compared.RESULTS:
DHEA and DHEA-S levels were significantly lower in the CFS compared to the healthy group; DHEA-S levels, but not DHEA, were lower in the depressives; cortisol and 17-alpha-hydroxyprogesterone did not differ between the three groups.CONCLUSIONS:
A potential role for DHEA, both therapeutically and as a diagnostic tool, in CFS, is suggested.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hidrocortisona
/
Síndrome de Fadiga Crônica
/
Desidroepiandrosterona
/
Transtorno Depressivo Maior
Aspecto:
Patient_preference
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Affect Disord
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Irlanda