Antibacterial activity of retinaldehyde against Propionibacterium acnes.
Dermatology
; 199 Suppl 1: 29-31, 1999.
Article
em En
| MEDLINE
| ID: mdl-10473957
ABSTRACT
BACKGROUND:
Retinaldehyde has been shown to exert antibacterial activity in vitro.AIM:
This study evaluates the effect of retinaldehyde on Propionibacterium acnes both in vivo and in vitro.METHODS:
Microbial minimal inhibitory concentrations (MICs) of retinaldehyde and retinoic acid were determined on reference strains of P. acnes. In vivo activity of daily topical application of 0.05% retinaldehyde on the P. acnes density was evaluated after application in a single-blind randomised study.RESULTS:
MICs of retinaldehyde were 4 mg/l for P. acnes No. CIP179 and CIP53119 and 8 mg/l for P. acnes No. CIP53117. In contrast, the MICs of retinoic acid were superior to 128 mg/l for these three strains. In vivo, retinaldehyde-treated areas displayed a significant decrease in counts of viable P. acnes as compared with the untreated areas with a median decrease of 10(2) log P. acnes/cm(2) after 2 weeks of daily application. Vehicle alone had no effect.CONCLUSION:
The MIC of retinaldehyde against P. acnes suggests a direct antibacterial activity. Daily topical application of 0.05% retinaldehyde is associated with a clear reduction of the P. acnes density.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Propionibacterium acnes
/
Retinaldeído
/
Pele
Tipo de estudo:
Clinical_trials
Limite:
Humans
Idioma:
En
Revista:
Dermatology
Assunto da revista:
DERMATOLOGIA
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Suíça