Procedure costs and outcomes associated with pharmacologic management of peripheral arterial disease in the Department of Defense.
Clin Ther
; 21(8): 1358-69, 1999 Aug.
Article
em En
| MEDLINE
| ID: mdl-10485507
ABSTRACT
This study was undertaken to determine if differences existed between pharmacologic treatments of peripheral arterial disease (PAD) with respect to PAD-related costs and health care outcomes in the United States Department of Defense health care system. We performed a retrospective review of hospital and prescription data to explore the effects of at least 90 days of aspirin, pentoxifylline, papaverine, or dipyridamole on 4 PAD-related outcomes:
number of PAD-related invasive procedures (INV), number of PAD-related examination procedures (EXM), number of PAD-related hospitalization days (HDAYS), and cost of PAD-related procedures (COST) during 5 years. A covariate representing the number of PAD-related hospitalizations before the study period was used to attempt to control for severity of disease state. General linear models were used in the analyses. A statistically significant difference was seen between treatment groups for a linear combination of INV, EXM, HDAYS, and COST when controlling for past PAD-related hospitalizations (P < 0.014). A statistically significant relationship existed between treatment groups and INV (P < 0.041). The pentoxifylline treatment group had a statistically significant higher covariate-adjusted mean INV compared with the aspirin treatment group (P < 0.043). Also, PAD-related past hospitalizations were significantly related to EXM (P < 0.006). Our results appear to support the use of aspirin as a preventive treatment in PAD compared with pentoxifylline or dipyridamole.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Farmacologia Clínica
/
Arteriosclerose
/
Doenças Vasculares Periféricas
/
Atenção à Saúde
Tipo de estudo:
Health_economic_evaluation
/
Observational_studies
/
Risk_factors_studies
Aspecto:
Determinantes_sociais_saude
Limite:
Adult
/
Humans
/
Middle aged
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Clin Ther
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Estados Unidos