Segmental specification of GABAergic inhibition during development of hindbrain neural networks.
Nat Neurosci
; 2(10): 873-7, 1999 Oct.
Article
em En
| MEDLINE
| ID: mdl-10491606
ABSTRACT
A primordial rhythm-generating neural network emerges during the segmental period of vertebrate hindbrain development, suggesting a common genetic basis to both the structure and network activity of the region. We show here that segmentation influenced a postsegmental developmental step by which a GABAergic rhythm generator was incorporated into the primordial network and increased rhythm frequency to near mature values. This process depended on specifications in r3 and r5 that controlled, on the basis of a two-segment repeat, later maturation of GABAergic inhibition.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Rombencéfalo
/
Ácido gama-Aminobutírico
/
Rede Nervosa
/
Inibição Neural
Limite:
Animals
Idioma:
En
Revista:
Nat Neurosci
Assunto da revista:
NEUROLOGIA
Ano de publicação:
1999
Tipo de documento:
Article