Effects of paroxetine on heart period variability in patients with panic disorder: a study of holter ECG records.
Neuropsychobiology
; 40(3): 124-8, 1999 Sep.
Article
em En
| MEDLINE
| ID: mdl-10494046
ABSTRACT
We investigated cardiac autonomic function in 16 patients with panic disorder before and after treatment with paroxetine using Holter ECG records. Our previous data suggest a relative increase in sympathetic activity in patients with panic disorder, especially during sleep. Data for 20 h and awake and sleep periods were analyzed using spectral analysis to quantify absolute and relative heart period variability in ultra low (ULF <0.0033 Hz), very low (VLF 0.0033-0.04 Hz), low (LF 0.04-0.15 Hz) and high (HF 0.15-0.5 Hz) frequency bands. We also obtained fractal dimensions (FD) for the 20-hour, awake and sleep time series of RR intervals. Paroxetine treatment (19.7 +/- 4.7 mg/day for 105 +/- 37 days) resulted in a significant improvement in the frequency and intensity of panic attacks and also on the state anxiety inventory. Paroxetine treatment produced a significant decrease of 20-hour absolute HF power, awake absolute LF power and sleep absolute HF power. There was also a significant decrease of FDs after treatment with paroxetine for the sleep period. The decrease in LF and HF powers, and sleep FD is likely due to the antimuscarinic effect of paroxetine. The decrease in day-time LF power may also be due to a decrease in relative cardiac sympathetic activity after paroxetine treatment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Eletrocardiografia Ambulatorial
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Transtorno de Pânico
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Inibidores Seletivos de Recaptação de Serotonina
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Paroxetina
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Frequência Cardíaca
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Neuropsychobiology
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Estados Unidos
País de publicação:
CH
/
SUIZA
/
SUÍÇA
/
SWITZERLAND