Strongyloides stercoralis: oral transfer of parasitic adult worms produces infection in mice and infection with subsequent autoinfection in gerbils.
Int J Parasitol
; 29(7): 1047-51, 1999 Jul.
Article
em En
| MEDLINE
| ID: mdl-10501615
ABSTRACT
Oral transfer of parasitic adult Strongyloides stercoralis produced patent infections in gerbils, C57BL/6J and SCID mice. In gerbils receiving adult worms, 7.3% of the transferred worms established and autoinfective L3 were found beginning on day 5 post-transfer, with peak numbers seen on days 6 and 7 post-transfer and few seen by 9 days post-transfer. These results suggest that development of autoinfective L3 in the gerbil is limited by the immune response of the host. When given orally to mice, between 7.2% (C57BL/6J) and 19.5% (SCID) of the adult worms established. These levels are higher than those previously obtained by the subcutaneous infection of SCID mice with infective larvae. No autoinfective larvae were found in infected mice and the ratio of L1/adult worms was small compared with that seen in gerbils. Thus, mice infected orally can be used as a model to study the interaction between the adult worm and the host, and since autoinfection has not been seen in the murine model, as developed to date, orally infected mice may be useful as a model to study mechanisms preventing autoinfection.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estrongiloidíase
/
Strongyloides stercoralis
/
Enteropatias Parasitárias
Limite:
Animals
Idioma:
En
Revista:
Int J Parasitol
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Estados Unidos