Vascular endothelial growth factor in pulmonary lavage fluid from premature infants: effects of age and postnatal dexamethasone.
Biol Neonate
; 76(5): 266-73, 1999 Nov.
Article
em En
| MEDLINE
| ID: mdl-10516393
ABSTRACT
Corticosteroids are used to ameliorate bronchopulmonary dysplasia (BPD). They also affect normal development, including the expression of growth factors such as vascular endothelial growth factor (VEGF). Deep pulmonary lavage specimens were collected on days 1, 3, 7 and 28 of life in 40 infants of <34 weeks of gestation at birth during a randomized controlled trial of two doses of dexamethasone (DEX) at 12 and 24 h of age for BPD prophylaxis. VEGF was measured by enzyme-linked immunosorbent assay. The 18 DEX and 21 control subjects had similar gestations, birth weights and oxygen requirements at study entry. Lavage VEGF tripled between day 1 and 3 in both groups. The day 7 levels were higher in DEX subjects than in controls. DEX and control values were similar on day 28. Higher lavage VEGF levels on days 1 and 3 were also correlated with lower gestational age at birth. Lavage VEGF levels were not associated with the development of BPD. We speculate that these DEX- and age-associated changes in VEGF may affect pulmonary angiogenesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Recém-Nascido Prematuro
/
Dexametasona
/
Líquido da Lavagem Broncoalveolar
/
Fatores de Crescimento Endotelial
/
Linfocinas
/
Pulmão
/
Anti-Inflamatórios
Tipo de estudo:
Clinical_trials
Limite:
Humans
/
Newborn
Idioma:
En
Revista:
Biol Neonate
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Estados Unidos