Molecular mechanisms of long-term potentiation in the insular cortex in vivo.
J Neurosci
; 19(21): RC36, 1999 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-10531470
ABSTRACT
We have investigated molecular mechanisms of synaptic plasticity in the pathway between two forebrain structures important for taste learning, the basolateral amygdala (BLA) and the insular cortex. We report here that in vivo long-term potentiation (LTP) induced by BLA stimulation requires functional NMDA receptors and is modulated by muscarinic acetylcholine receptors. In addition, LTP results in the activation of cortical extracellular regulated kinase 1/2 (ERK1/2) and is blocked by inhibitors of ERK1/2 activation. Previous findings demonstrated the involvement of the same molecular mechanisms in the same cortical area during novel taste learning. The results demonstrate that both synaptic and behavioral plasticity share common molecular mechanisms in the insular cortex.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Córtex Cerebral
/
Receptores Muscarínicos
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Receptores de N-Metil-D-Aspartato
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Potenciação de Longa Duração
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Tonsila do Cerebelo
/
Aprendizagem
Limite:
Animals
Idioma:
En
Revista:
J Neurosci
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Reino Unido