Implications of histological grade of tumour for the prognosis of radically resected periampullary adenocarcinoma.
Eur J Surg
; 165(9): 865-70, 1999 Sep.
Article
em En
| MEDLINE
| ID: mdl-10533763
ABSTRACT
OBJECTIVE:
To study the influence of histological grade of tumour on the prognosis of radically resected periampullary cancers.DESIGN:
Retrospective study.SETTING:
Teaching hospital, Austria.SUBJECTS:
156 patients (papilla of Vater, n = 34, head of the pancreas, n = 105, and distal common bile duct, n = 17) who underwent partial pancreaticoduodenectomy for periampullary adenocarcinoma between 1 January, 1967 and 31 December, 1996. OUTCOMEMEASURES:
The relation between grade of tumour and site, T and N classification, extramural growth, invasion of vessels and resection margins, tumour volume, and survival time.RESULTS:
Well differentiated lesions were significantly more common in the papilla of Vater (n = 15, 44%, p = 0.01) than in the pancreatic head or the common bile duct (n = 20, 19%, and n = 5, 29%, respectively). Only in ampullary lesions did the grade of tumour significantly affect the incidence of other histopathological risk factors (T p = 0.003; nodal status p = 0.01; extramural growth p = 0.0001; tumour volume p = 0.02) and survival time (p = 0.02); no significant correlations were found in cancers of the head of the pancreas or common bile duct.CONCLUSIONS:
There was a significant difference in the distribution of grade of tumour between the different sites of origin of resected periampullary cancers. Grade of tumour correlated with T and N classification, tumour volume, extramural growth, and survival only in ampullary lesions.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
/
Ampola Hepatopancreática
/
Adenocarcinoma
/
Neoplasias do Ducto Colédoco
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
/
Middle aged
Idioma:
En
Revista:
Eur J Surg
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Áustria