Visual and ocular outcome in children after prenatal exposure to antiepileptic drugs.
Acta Ophthalmol Scand
; 77(5): 530-5, 1999 Oct.
Article
em En
| MEDLINE
| ID: mdl-10551294
ABSTRACT
PURPOSE:
To prospectively study the incidence of structural and/or functional ophthalmological abnormalities in the offspring to an unselected population of women with epilepsy, subjected to a well controlled antiepileptic drug (AED) treatment during pregnancy.METHODS:
Forty-three children prenatally exposed to antiepileptic drugs and 47 controls were included. Blinded ophthalmological examinations including fundus photography were performed at a median age of 7 years and 4 months.RESULTS:
No major eye anomalies were found except in one child in the exposed group who had nystagmus and low vision. The visual acuity was lower in the eye with lowest acuity among the exposed children (p < 0.05). No other significant difference was found between the two groups.CONCLUSION:
The results suggest that a well-controlled treatment with AEDs, preferably monotherapy, during pregnancy does not have any major adverse effects on the development of the eye and ophthalmological functions.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Efeitos Tardios da Exposição Pré-Natal
/
Visão Ocular
/
Olho
/
Anticonvulsivantes
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Limite:
Child
/
Female
/
Humans
/
Male
/
Pregnancy
Idioma:
En
Revista:
Acta Ophthalmol Scand
Assunto da revista:
OFTALMOLOGIA
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Suécia