Oncogenic role of Epstein-Barr virus-encoded RNAs in Burkitt's lymphoma cell line Akata.
J Virol
; 73(12): 9827-31, 1999 Dec.
Article
em En
| MEDLINE
| ID: mdl-10559294
ABSTRACT
Our previous reports indicated that Epstein-Barr virus (EBV) contributes to the malignant phenotype and resistance to apoptosis in Burkitt's lymphoma (BL) cell line Akata (N. Shimizu, A. Tanabe-Tochikura, Y. Kuroiwa, and K. Takada, J. Virol. 686069-6073, 1994; J. Komano, M. Sugiura, and K. Takada, J. Virol. 729150-9156, 1998). Here we report that the EBV-encoded small RNAs (EBERs) are responsible for these phenotypes. Transfection of the EBER genes into EBV-negative Akata clones restored the capacity for growth in soft agar, tumorigenicity in SCID mice, resistance to apoptotic inducers, and upregulated expression of bcl-2 oncoprotein that were originally retained in parental EBV-positive Akata cells and lost in EBV-negative subclones. This is the first report which provides evidence that virus-encoded RNAs (EBERs) have oncogenic functions in BL cells.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
RNA Viral
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Transformação Celular Neoplásica
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Transformação Celular Viral
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Linfoma de Burkitt
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Herpesvirus Humano 4
Limite:
Animals
Idioma:
En
Revista:
J Virol
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Japão