[Experimental research on the use of deferoxamine in the prevention of renal damage from acute ischemia]. / Ricerche sperimentali sull'impiego della deferoxamina nella prevenzione del danno renale da ischemia acuta.

ABSTRACT

Oxygen free-radical reperfusion products play a critical role in postischemic tissues injury. In this study we used deferoxamine, an iron ligand that seems to inhibit hydroxyl radicals production, in renal normothermic acute ischemia in the rat. Our results demonstrated a significant protective effect of deferoxamine on kidneys subjected to normothermic acute ischemia.