Organogenic role of B lymphocytes in mucosal immunity.
Science
; 286(5446): 1965-8, 1999 Dec 03.
Article
em En
| MEDLINE
| ID: mdl-10583962
ABSTRACT
Follicle-associated epithelium (FAE) in the intestinal Peyer's patches contains M cells that deliver pathogens to organized lymphoid tissue. Development of Peyer's patches, FAE, and M cells was found to be impaired in mice that had no B cells. Transgenic expression of membrane-bound immunoglobulin M restored B cells and FAE development. The lack of M cells abrogated infection with a milk-borne retrovirus. Thus, in addition to secretion of antibodies and presentation of antigens, B cells are important for organogenesis of the mucosal immune barriers.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nódulos Linfáticos Agregados
/
Linfócitos B
/
Imunidade nas Mucosas
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Estados Unidos