Activation of adenylate cyclase results in down-regulation of c-jun mRNA expression in rat C6 glioma cells.
Neurosci Lett
; 276(1): 53-6, 1999 Nov 26.
Article
em En
| MEDLINE
| ID: mdl-10586973
ABSTRACT
To investigate the possible mechanisms involved in forskolin-induced c-jun mRNA decrease in rat C6 glioma cells, we examined effects of a PKA inhibitor (H-89), a L-type Ca2+ channel blocker (nimodipine), a calmodulin activation inhibitor (calmidazolium chloride) and a Ca2+/calmodulin-dependent protein kinase II inhibitor (KN-62) on forskolin-induced c-jun mRNA down-regulation. H-89 caused a reversal of forskolin-induced c-jun mRNA decrease. Furthermore, nimodipine, KN-62 and calmidazolium chloride partially blocked forskolin-induced c-jun mRNA down-regulation. Our results suggest that activation of adenylate cyclase appears to be involved in a down-regulation of c-jun mRNA expression through a PKA pathway. In addition, L-type calcium channels, calmodulin and Ca2+/calmodulin-dependent protein kinase II may be partially involved in c-jun mRNA down-regulation induced by forskolin.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sulfonamidas
/
RNA Mensageiro
/
Regulação para Baixo
/
Adenilil Ciclases
/
Proteínas Proto-Oncogênicas c-jun
/
Glioma
Limite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Coréia do Sul