12-Lipoxygenase products increase monocyte:endothelial interactions.
Adv Exp Med Biol
; 469: 455-60, 1999.
Article
em En
| MEDLINE
| ID: mdl-10667368
ABSTRACT
In summary, we suggest that hyperglycemia causes upregulation of 12-lipoxygenase activity. The increased production of 12-LO products, 12(S) and 15(S)-HETE, activates monocyte integrins which result in enhanced adhesion of monocytes to endothelium. The binding of monocytes to endothelium is a key early event in development of atherosclerosis. Upregulation of this process by vascular cells exposed to chronic elevations in glucose may be one explanation for the accelerated atherosclerosis observed in patients with Type 2 diabetes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Araquidonato 12-Lipoxigenase
/
Endotélio Vascular
/
Monócitos
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Adv Exp Med Biol
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Estados Unidos