Cells containing immunoreactive estrogen receptor-alpha in the human basal forebrain.
Brain Res
; 856(1-2): 142-51, 2000 Feb 21.
Article
em En
| MEDLINE
| ID: mdl-10677621
ABSTRACT
The distribution of estrogen receptor protein-alpha (ER-alpha)-containing cells in the human hypothalamus and adjacent regions was studied using a monoclonal antibody (H222) raised against ER-alpha derived from MCF-7 human breast cancer cells. Reaction product was found in restricted populations of neurons and astrocyte-like cells. Neurons immunoreactive for ER-alpha were diffusely distributed within the basal forebrain and preoptic area, infundibular region, central hypothalamus, basal ganglia and amygdala. Immunoreactive astrocyte-like cells were noted within specific brain regions, including the lamina terminalis and subependymal peri-third-ventricular region. These data are consistent with the location of estrogen receptors in the basal forebrain of other species and the known effects of estrogens on the cellular functions of both neurons and supporting elements within the human hypothalamus and basal forebrain.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Receptores de Estrogênio
/
Astrócitos
/
Prosencéfalo
/
Hipotálamo
/
Neurônios
Limite:
Female
/
Humans
Idioma:
En
Revista:
Brain Res
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos