Role of neurotrophins in the development and plasticity of the visual system: experiments on dark rearing.
Int J Psychophysiol
; 35(2-3): 189-96, 2000 Mar.
Article
em En
| MEDLINE
| ID: mdl-10677647
ABSTRACT
An extensive series of studies, beginning with the pioneering experiments of Wiesel and Hubel, have shown that correct visual experience is crucial for the development of the visual system. Several years ago, we put forward the hypothesis that neurotrophic factors of the neurotrophin family (NGF, BDNF, NT-3, NT-4) have a role in mediating the effects of visual experience in the developing visual system. This theory is based on the following experimental results:
(a) exogenous supply of neurotrophins during the critical period prevents the effects of monocular deprivation; and (b) transplant of cells releasing NGF allows a normal development of the functional properties of visual cortical neurons in dark-reared rats.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Visão Ocular
/
Escuridão
/
Fatores de Crescimento Neural
/
Plasticidade Neuronal
Limite:
Animals
Idioma:
En
Revista:
Int J Psychophysiol
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Itália