Impaired nitrergic relaxations in the gastric fundus of dystrophic (mdx) mice.
Neurosci Lett
; 282(1-2): 105-8, 2000 Mar 17.
Article
em En
| MEDLINE
| ID: mdl-10713407
ABSTRACT
Relaxant responses to electrical field stimulation (EFS) were investigated in the gastric longitudinal fundus strips from young normal and mdx dystrophic mice, an animal model of Duchenne muscular dystrophy. In carbachol (CCh) precontracted strips from normal mice, EFS elicited brisk relaxant responses that, depending on stimulation frequency, could be followed by a sustained relaxation. In strips from mdx mice the brisk relaxation was impaired. Smooth muscle responses to direct stimulating agents did not differ in amplitude between the two groups of animals. In strips from both normal and mdx mice, N(G)-nitro-L-arginine (L-NNA) abolished the brisk phase of relaxation, without affecting the sustained response. alpha-chymotrypsin abolished, in both preparations, the sustained relaxant response to EFS as well as relaxation to vasoactive intestinal polypeptide. Results suggest that, in strips from mdx mice, a defective production/release of the neurotransmitter responsible for the brisk relaxation, likely nitric oxide, occurs.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Distrofia Muscular de Duchenne
/
Fundo Gástrico
/
Óxido Nítrico
Limite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Itália