Molecular imaging of stretch-induced tissue factor expression in carotid arteries with intravascular ultrasound.
Invest Radiol
; 35(4): 227-34, 2000 Apr.
Article
em En
| MEDLINE
| ID: mdl-10764091
ABSTRACT
RATIONALE AND OBJECTIVES:
Molecular imaging with targeted contrast agents enables tissues to be distinguished by detecting specific cell-surface receptors. In the present study, a ligand-targeted acoustic nanoparticle system is used to identify angioplasty-induced expression of tissue factor by smooth muscle cells within carotid arteries.METHODS:
Pig carotid arteries were overstretched with balloon catheters, treated with tissue factor-targeted or a control nanoparticle system, and imaged with intravascular ultrasound before and after treatment.RESULTS:
Tissue factor-targeted emulsions bound and increased the echogenicity and gray-scale levels of overstretched smooth muscle cells within the tunica media, versus no change in contralateral control arteries. Expression of stretch-induced tissue factor in carotid artery media was confirmed by immunohistochemistry.CONCLUSIONS:
The potential for abnormal thrombogenicity of balloon-injured arteries, as reflected by smooth muscle expression of tissue factor, was imaged using a novel, targeted, nanoparticulate ultrasonic contrast agent.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tromboplastina
/
Artérias Carótidas
/
Músculo Liso Vascular
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Invest Radiol
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos