Effect of high-grade prostatic intraepithelial neoplasia on total and percent free serum prostatic-specific antigen.
Eur Urol
; 37(4): 456-9, 2000 Apr.
Article
em En
| MEDLINE
| ID: mdl-10765077
ABSTRACT
OBJECTIVE:
To analyze the influence of high-grade prostatic intraepithelial neoplasia (HGPIN) on total serum prostatic-specific antigen (PSA) and percent free PSA.METHODS:
Total and free serum PSA were determined in 81 consecutive patients with clinical T1c prostate cancer who underwent radical prostatectomy. HGPIN was detected in 62 specimens (76.5%).RESULTS:
Median total PSA was 9.2 ng/ml when there was not HGPIN and 8.1 ng/ml when it existed, p>0.05. Median percent free PSA was 11.7 and 9.1%, respectively, p<0.03. However, a multiple linear regression analysis demonstrated there was no effect of HGPIN on total PSA nor on percent free PSA. Percent free serum PSA was significantly influenced by total PSA and the pathological tumor stage.CONCLUSION:
HGPIN does not seem to contribute significantly on serum total PSA and percent free PSA.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Antígeno Prostático Específico
/
Neoplasia Prostática Intraepitelial
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adult
/
Aged
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Eur Urol
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Espanha