Canine transmissible venereal tumour: a morphological and immunohistochemical study of 11 tumours in growth phase and during regression after chemotherapy.
J Comp Pathol
; 122(4): 241-8, 2000 May.
Article
em En
| MEDLINE
| ID: mdl-10805977
ABSTRACT
Eleven dogs with canine transmissible venereal tumour (CTVT) were given vincristine sulphate chemotherapy to induce tumour regression. Biopsy specimens were collected from tumours during the growth phase, before chemotherapy, and again from the same dogs during the regression induced by chemotherapy. Laboratory assessment included cytology, histology, the number of tumour cells in relation to the number of intratumoral leucocytes, proliferative and apoptotic fractions of tumour cells, intratumoral vessel density, and fibrosis. The results revealed that during regression, tumour cell proliferation ceased, apoptosis increased, leucocytes increased (with increased proportion of T lymphocytes), tumour parenchyma collapsed around intratumoral vessels, and fibrosis increased. These results, which were similar to findings in dogs with spontaneous regression of CTVT, suggest that tumour immunity plays a role in tumour regression after modest chemotherapy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tumores Venéreos Veterinários
/
Doenças do Cão
Limite:
Animals
Idioma:
En
Revista:
J Comp Pathol
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Chile